Hereditary Mutation |
DMD can be passed down through genetics, even if only one person in the biological family has it. In which, this is the way genetic diseases are inherited.
DMD, inherited in an X-linked pattern, is a gene that can carry DMD -causing mutation on the X chromosomes. Every male inherits an X chromosome from his mother and a Y chromosome from his father, determining that he is a boy. Each son i born to a woman with a dystrophin mutation from either one of her X chromosomes, has a 50 percent chance of inheriting the abnormal gene and having DMD or BMD. Each of her daughters also has a 50 percent chance of inheriting the mutation and being a carrier. Carriers typically do not have the disease symptoms, though can have a child with the mutation of the disease. DMD and BMD carriers are at risk for cardiomyopathy, that is a chronic disease of the heart muscle. A family with no history of DMD or BMD can suddenly have a child who inherits the abnormal gene. There are two possible explanations.
|
A male with DMD or BMD is unable to pass the abnormal gene to his sons as he gives a son a Y chromosome, not an X. Though, there is a possibility he can pass it to his daughter, as each daughter inherits her father’s only X chromosomes. They’ll then be the carriers, and each of their sons then will have a 50 percent possibility of developing the disease, and so on.
|
Females with DMD
|